Open access
Oct 2026
Identification of AHR, UACA, GCLM, and GSTZ1 as candidate genes associated with metabolic alterations in intervertebral disc degeneration
A miRNA–transcription factor–mRNA regulatory network was constructed and validated core gene dysregulation via RT-qPCR in primary human nucleus pulposus cells, providing candidate molecular indicators for IVDD severity assessment and insights for future mechanistic studies.
Zhong-Hua Zhang, Meng-Yang Li, M. Dong et al.
· Scientific Reports · 0 citations