Triple-negative breast cancer (TNBC), characterized by aggressive behavior and poor prognosis, presents a formidable clinical challenge. Despite guideline endorsement of chemoimmunotherapy as a standard treatment in TNBC, durable responses remain rare, largely due to an immunologically “cold” tumor microenvironment (TM...
Xin Li, Tong Chen, Wen-Jing Zhao et al.· Journal of Clinical Investig...· 0 citations
ABSTRACT Breast cancer is the leading malignancy among women worldwide, with triple‐negative breast cancer (TNBC) representing the most aggressive subtype. Accumulating evidence highlights glucose metabolism reprogramming as a critical driver of TNBC progression and immune evasion, yet the underlying molecular mechanis...
Yuhan Jin, Wen-Jing Zhao, Lei Wang et al.· Advancement of science· 0 citations
These findings uncover a CAF‐exosomal circFAD104 axis that reprograms glucose metabolism to drive TNBC progression via the circFAD104/MARCHF8/PGM1 pathway, highlighting its potential as a stroma‐targeted biomarker and prognostic predictor.
Lei Wang, Xiaoyan Li, Yi-Ran Liang et al.· Advancement of science· 0 citations
We use cookies to run the site and, with your consent, for analytics and to show ads.
See our Cookie Policy.