Bing-Hua Zhang

Pd/Cu Synergistic Catalysis for Difluorocarbene-Mediated Synthesis of Carbamoyl-Substituted Oxindoles.

A palladium-catalyzed tandem Heck cyclization of N-(2-iodoaryl)acrylamides with N-methylanilines and ClCF2COONa has been developed for the synthesis of carbamoyl-substituted oxindoles bearing an all-carbon quaternary stereocenter, wherein difluorocarbene serves as the carbonyl source. This method operates under mild co...