Aug 2026
BLU-945 suppresses ABCB1-mediated drug efflux and restores chemosensitivity in multidrug-resistant cancer cells.
BLU-945 may serve as a dual-function agent capable of targeting oncogenic signaling while mitigating transporter-mediated chemoresistance, supporting its potential reprofiling in combination chemotherapy for ABCB1-overexpressing tumors.
Chung-Pu Wu, Yen-Ching Li, Ting-Yu Chen et al.
· European Journal of Pharmaco... · 1 citation