The rise in antimicrobial resistance (AMR) demands new treatments, especially for biofilm-associated infections where bacteria tolerate antibiotics. Escherichia coli O157:H7 (E. coli O157) is a virulent foodborne pathogen that causes severe haemorrhagic colitis and haemolytic uraemic syndrome. The LuxS/AI-2 quorum sens...
Hong-Xing Zhang, Jing Xu, Wen-Kui Bao et al.· Biomolecules· 0 citations
Conventional bactericidal antibiotics often fail to eradicate Escherichia coli O157:H7 (
E. coli
O157) infections due to biofilm-mediated antimicrobial tolerance, and monotherapy can inadvertently drive resistance selection. This study aimed to identify compounds capable of modulating LuxS/AI-2-related phenotyp...
Hong-Xing Zhang, Jing Xu, Ya-Xin Zhou et al.· Frontiers in Microbiology· 0 citations
Pseudomonas aeruginosa employs quorum sensing (QS) to coordinate biofilm formation and virulence factor expression, positioning QS as a promising target for anti-infective interventions. This study evaluated the antibiofilm and antivirulence efficacy of 2-methoxy-1,4-naphthoquinone (MNQ), a natural naphthoquinone, agai...
Background: The rapid emergence of antibiotic resistance in E. coli has outpaced the development of new drugs, creating an urgent demand for novel therapeutic strategies. Methods: We screened ten antibiotics in combination with isochlorogenic acid C (ICAC) against multidrug-resistant (MDR) E. coli. Synergistic effects...
Yu-Bin Bai, Xu Chen, Rong-Bin Hu et al.· Biomolecules· 0 citations
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