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Author

Bing Lian

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Open access Oct 2026

Lactylation-driven mitochondrial dysfunction promotes diabetic myocardial fibrosis via impairing mitophagy and activating TGF-β1

This study aimed to investigate the role and mechanisms of lactate-derived protein lactylation in promoting myocardial fibrosis in diabetic cardiomyopathy (DCM). We hypothesized that lactylation contributes to fibrosis through dual pathways: impairing PINK1/Parkin-mediated mitophagy and epigenetically activating the TG...

Bing Lian, Jun-Yan Li, Yong-Long Guo et al. · 0 citations

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