Open access
Aug 2026
Listeria promotes systemic infection by targeting the host deubiquitinase CYLD
Listeria monocytogenes (Lm) is an intracellular pathogen that can cause life-threatening systemic infections. Internalin C (InlC) is a secreted factor required for full Lm virulence in systemic models of infection by mechanisms that remain unclear. Here, we show that InlC binds to CYLD, a host deubiquitinase and regula...
Dustin A. Ammendolia, Cara J. Ellison, Yue-Lin Zheng et al.
· Nature Communications · 0 citations