Author

Bing Shi

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Open access Oct 2026

Targeted tumor desialylation by engineered probiotic reprograms the tumor microenvironment to potentiate immunotherapy

Tumor hypersialylation drives immunosuppression and limits immunotherapy efficacy by shielding tumor cells and engaging inhibitory immune receptors. Here, we engineered Escherichia coli Nissle 1917 (EcNΔpgi-SAS) as a metabolically confined “desialylation catalyst” to remodel the tumor microenvironment. This strain comb...

Jin-Hui Wang, Jing Wang, Tao Ouyang et al. · bioRxiv · 0 citations

Open access Aug 2026

Bacteria-Mediated Targeted Delivery and Deep Tumor Penetration of a Pt(IV)-Drug Enables Synergistic Chemo-Immunotherapy.

Platinum-based drugs are clinically vital for cancer treatment but suffer from off-target cytotoxicity and poor tumor penetration. To overcome these limitations, we designed a tumor-targeted Pt(IV) drug-bacteria conjugate (Pt-EcN-HER2). This conjugate exploits the inherent tumor tropism of probiotic bacterium Escherich...

He Meng, Jin-Hui Wang, Bing Shi et al. · Angewandte Chemie · 0 citations