IGF2BP3 drives macrophage M1 polarization to promote intracranial aneurysm rupture through m6A-mediated NPY1R stabilization.
BACKGROUND The progression of intracranial aneurysm (IA) was closely associated with an imbalance in M1/M2 macrophage polarization. Neuropeptide Y receptor 1 (NPY1R) was involved in regulating IA development. However, NPY1R in IA-associated macrophages and its impact on macrophage polarization remain to be elucidated....