Elevation of Beta-2 Microglobulin during Prion Infection is Closely Correlated with PrPSc Accumulation and is Independent of MHC-I.
β2-microglobulin (B2M) is implicated in neuroinflammatory and neurodegenerative processes, but its role in prion diseases remains unclear. Here, the alterations in B2M expression and distribution as well as its correlation with PrPSc accumulation were investigated in several scrapie-infected rodent models and a prion-i...