Oct 2026
Liver-Targeted DGAT2 siRNA Ameliorates Steatosis and Fibrosis in a High-Fat Diet-Induced MASH Mouse Model.
Diacylglycerol O-acyltransferase 2 (DGAT2), a key enzyme in hepatic triglyceride (TG) synthesis, is considered a promising therapeutic target for metabolic dysfunction-associated steatohepatitis (MASH). Small interfering RNAs (siRNAs) targeting conserved regions of human and mouse DGAT2 mRNA were designed, synthesized,...
En-Hua Zhang, Wei Zheng, Yi-Zhe Li et al.
· Journal of drug targeting (P... · 0 citations