Aug 2026
Blocking the RhoA/ROCK/cofilin/F-actin Pathway via Y27632 Protects Against MERTK-deficient Retinal Degeneration and Visual Function Impairment.
It is shown that MERTK maintains RPE survival and phagocytosis via regulating the RhoA/ROCK/cofilin/F-actin axis and rescued the MERTK depletion-induced phagocytic dysfunction and apoptosis of HsRPE cells and rat RPE.
Lujia Feng, Ting Zhang, Yong Du et al.
· Current Medicinal Chemistry · 0 citations