Review
Open access
Oct 2026
Context- and Cell-Dependent Roles of S1PR1 in Atherosclerosis: Therapeutic Implications of Selective S1PR1 Modulation
Sphingosine 1-phosphate receptor 1 (S1PR1) regulates vascular homeostasis and immune function, but its role in atherosclerosis has remained controversial because activating the same receptor produces divergent effects across cell types. This review synthesizes evidence on S1PR1 signaling in endothelial cells, macrophag...
Thang Nguyen Ngoc, Shih-Chang Hsu, Ching-Lu Chen et al.
· Artery Research · 0 citations