TREM2 signaling in cardiovascular disease: macrophage heterogeneity, timing, and therapeutic opportunity.
This review systematically delineates the spatiotemporal dynamics and functional duality of TREM2+ macrophages across major cardiovascular conditions, and further evaluates the current evidence and limitations of soluble TREM2 (sTREM2) as a candidate biomarker and critically appraises translational strategies targeting...