Open access
Aug 2026
Identification of SKI-II as a host-protective immunomodulator against Staphylococcus aureus infection
This work identifies VCP as a druggable node for host-directed immunomodulation and highlights SKI-II as a prototype small molecule that boosts host tolerance to infection, thereby validating the C. elegans-based screening platform for discovering immunomodulators active in mammalian systems.
Li-Yang Zhang, Kai Ye, Charilaos Dellis et al.
· mBio · 0 citations