Circulating cell-cell complexes (doublets) provide critical insights into in vivo immune interactions. Here, we leverage high-dimensional imaging spectral cytometry to systematically map the landscape of immune doublets in human peripheral blood. By integrating morphometric imaging features with a 22-color spectral pan...
Cheryl Kim, Denise Hinz, Aaron Middlebrook et al.· bioRxiv· 0 citations
This study used single-cell RNA sequencing to provide a high-resolution characterization of CD4−CD8− γδ T cells in peripheral blood across healthy Mtb-(non-)sensitized and TB disease pre-/post-treatment cohorts and found an activated and cytotoxic gene signature in γδ T cells of TB disease compared with both healthy co...
Kendall Kearns, R. Tippalagama, Ashu Chawla et al.· iScience· 0 citations
A CDM for the Adaptive Immune Receptor Repertoire Knowledge Commons was designed based upon the Ontology for Biomedical Investigations, a community standard for scientific data integration, and the LinkML data modeling language was used for implementation.
Scott Christley, Felix Breden, Kevin A. Burns et al.· Journal of Immunology· 0 citations
Using the recently commercialized FACSDiscoverTM S8 spectral imaging cell sorter, image-based cell sorting provides unprecedented granularity in the study of immune doublets and enrichment for biological doublets over technical artifacts.
Ning-Xin Kang, Cheryl Kim, Thomas J. Scriba et al.· Journal of Immunology· 0 citations
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