Björn Corleis

Species-specific iNOS expression distinguishes epithelial and myeloid IFNγ responses in tuberculosis.

RATIONALE Tuberculosis vaccines aim to elicit protective immunity, with IFNγ-producing CD4⁺ T cells considered central mediators of host defense. In murine models, IFNγ activates macrophages to induce inducible nitric oxide synthase (iNOS), resulting in nitric oxide-dependent control of Mycobacterium tuberculosis (Mtb)...