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Author

Bohan Zhu

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Open access Sep 2026

Directing GABAergic neuronal identity from human iPSCs through developmental patterning.

It is shown that the chromatin state of the starting population constrains the neuronal identities specified by ASCL1 and DLX2, and it is demonstrated that the recurrent p.Tyr719∗ mutation disrupts interneuron maturation and subtype-associated transcriptional programs and impairs inhibitory synaptic transmission in hum...

Rui-Qi Hu, Linda L. Boshans, Yi-Ran Tao et al. · 0 citations
Open access Jul 2026

Uhrf1 loss disrupts Ctcf-associated chromatin organization during early mouse embryogenesis

These findings identify Uhrf1 as a central regulator that tightly couples DNA methylation maintenance to 3D genome organization during gastrulation, thereby, directing early lineage specification and positioning Uhrf1 as a pivotal mediator of epigenetic information transfer during early embryogenesis.

Agata Kurowski, Bohan Zhu, Yifei Sun et al. · 0 citations

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