Bo-Hao Duan

Structural basis of enzymatic functional divergence in the PAL gene family of Salix brachista: Allosteric regulation and catalytic activity mediated by non-catalytic sites.

Phenylalanine ammonia-lyase (PAL) is the rate-limiting enzyme of the plant phenylpropanoid pathway, and its functional divergence is closely associated with environmental adaptation. Using the alpine woody plant Salix brachista as a model, we integrated multi-omics and molecular modeling approaches to systematically ch...