Aug 2026
Semi-synthesis and activity study of α-mangostin ether derivatives bearing N-heterocyclic side chains as multitarget-directed ligands against AD.
This work employed regioselective Williamson O-alkylation to semi-synthesize three novel α-M alkylamine derivatives, enabling tunable mono- and disubstitution, highlighting the potential of tunable α-M derivatives as promising anti-AD candidates.
Bo-Kai Zhang, Yu Li, Xiao-Li Qiao et al.
· Bioorganic & Medicinal Chemi... · 0 citations