Open access
Jan 2026
Under Chronic, High‐Dose Administration of Wenjing Decoction, the Activation of the Hepatic Nrf2/HO‐1 Pathway Mediates Increased Bilirubin Levels and Associated Reversible Neurologic Dysfunction in Mice
Long‐term and high‐dose exposure to WJD can induce hyperbilirubinemia in mice by activating the hepatic Nrf2/HO‐1 signaling pathway, as well as causing mild hepatic oxidative damage and neurobehavioral abnormalities.
Wei Du, Min Wang, Xiaoxian Song et al.
· Journal of Toxicology · 0 citations