Mechanistic investigations revealed that 8j induces G1 phase cell cycle arrest and promotes apoptosis, which was corroborated by the observed concentration-dependent downregulation of key cell cycle regulators, including CDK4 and cyclin D1.
Chao Lin, Shao-Feng Sun, Hua-Teng Zhang et al.· Journal of Enzyme Inhibition...· 0 citations
An in-depth exploration of advanced nano-therapeutic strategies designed to multi-target angiogenic pathways, dynamically manipulate reactive oxygen species, disrupt hypoxia-driven feedback loops, reprogram the immunoinflammatory network, and restore defective cellular autophagy are provided.
Xiao-Yan Lu, Bo Li, Bao-Yuan Sun et al.· European journal of pharmace...· 0 citations
This review summarizes recent advances in stem cell and exosome-based treatments for dry eye disease and analyzes their current regulatory landscapes, intending to serve as a reference for investigators within the field.
Hua-Teng Zhang, Lei-Qing Wang, Chao Lin et al.· Sheng wu yi xue gong cheng x...· 0 citations
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