Open access
Sep 2026
Dioscin activates myeloid AMPK to restore Lgr5⁺ stem cell homeostasis and promote mucosal repair in ulcerative colitis.
Dioscin ameliorates experimental colitis and dysplasia by activating myeloid AMPK signaling, inhibiting IL-1β-driven macrophage-ISC dysregulation, and restoring epithelial regeneration, highlighting macrophage metabolic reprogramming as a therapeutic strategy and identifying myeloid AMPK as a potential target for UC in...
Nian-Ka Huang, Shu-Ru Lu, Qiu-Wei Zhong et al.
· Pharmacological Research · 0 citations