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Bo Shu

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Open access Oct 2026

Fusion-loop-engineered Zika mRNA vaccine elicits convergent B cell immunodominance to uncouple protection from ADE in macaques.

Antibody-dependent enhancement (ADE) remains a major hurdle for flavivirus vaccine development. Engineering the fusion loop (FL) represents a promising solution, yet validations restricted to murine models limit human translatability due to profound species divergence. Here, we provide a primate-level demonstration tha...

Chen-Xi Yang, Shu-Xin Guo, Ya-Ming Lu et al. · 0 citations

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