An endogenous retinoic acid response element enhancer controls Cyp26a1-mediated retinoic acid clearance during embryonic stem cell differentiation.
Precise control of retinoic acid (RA) signaling is essential for embryonic development, as fluctuations in RA availability can perturb cell fate determination and contribute to severe developmental abnormalities. Yet how inducible RA clearance is encoded within endogenous chromatin during pluripotent cell differentiati...