Author

Bo-Wen Li

2 papers indexed here

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Review Sep 2026

Temozolomide resistance in glioblastoma: Multidimensional networks, core signaling hubs, and targeted therapeutic strategies.

Glioblastoma (GBM) represents the most aggressive primary malignant tumor of the adult central nervous system, with an extremely poor clinical prognosis. As the first-line chemotherapeutic agent for GBM, temozolomide (TMZ) has encountered a critical therapeutic bottleneck due to the development of drug resistance in tu...

Ying Qin, Yu-Fang Zhao, Bo-Wen Li et al. · Biochimica et biophysica act... · 0 citations

Review Open access Sep 2026

Context-dependent roles of cGAS-STING signaling in glioblastoma: Therapeutic resistance, drug delivery, and heterogeneity-informed translation.

A heterogeneity-informed framework for patient stratification and precision immunotherapy development in GBM is proposed, and major translational challenges are highlighted, including blood-brain barrier penetration, cell-type-specific pathway activation, treatment-induced pathway remodeling, and biomarker selection.

Yu-Zhu Long, Tong-Cui Jiang, Yu Long et al. · Biomedicine & pharmacotherap... · 0 citations