Open access
Sep 2026
EphB1 Receptor Blockade Augments Morphine Antinociception via Inhibiting GRK2‐Mediated µ‐Opioid Receptor Internalization
ABSTRACT Opioids are the primary treatment for severe pain in clinical practice. However, repeated exposure to opioids leads to tolerance, and underlying mechanisms remain elusive. The present study demonstrates that EphB1 receptors play an important role in opioid antinociception through orchestrating µ‐opioid recepto...
Bo Peng, Xia-Qing Lin, Hong-Yu Yao et al.
· Advancement of science · 0 citations