Multifunctional platinum(IV) prodrugs: Targeted delivery, stimuli-responsive release, and precision oncology.
Platinum-based chemotherapy remains the cornerstone of cancer treatment, but it faces inherent limitations such as dose-limiting toxicity, acquired resistance, and poor tumor specificity. Platinum(IV) prodrugs, with their octahedral configuration and two modifiable axial sites, have evolved into multifunctional platfor...