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Open access Aug 2026

TDP-43 drives ferroptosis evasion by modulating PCBP1/PCBP2 axis to promote lung adenocarcinoma growth

It is reported that TDP-43 acts as a key ferroptosis regulator facilitating LUAD growth, and whole transcriptome sequencing combined with subsequent validation assays revealed that TDP-43 is capable of suppressing ferroptosis in LUAD cells.

Bo-Wen Liu, Xin Chen, Jingjing Chen et al. · 0 citations
Open access Jul 2026

ORC6 marks a replication-active malignant epithelial state and is associated with immune-low features in oral squamous cell carcinoma

Introduction Oral squamous cell carcinoma (OSCC) shows marked biological heterogeneity, but markers that connect malignant epithelial states with the tumor immune context remain limited. Origin recognition complex subunit 6 (ORC6) participates in DNA replication licensing, but its disease-specific role in OSCC is not w...

Shaofu Yan, Wenqi Tan, Yanxin Zhang et al. · 0 citations

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