What are the fundamental units of protein sequences? Most protein language models treat amino acids as tokens, yet biological functions are not encoded at the single-residue level. Instead, they emerge from combinations of residues that form functional units that corresponds to conserved sequence motifs. Just like how...
Boon How Low, Wen Y. Goh, Bo-Yang Li et al.· Proceedings of the 32nd ACM...· 0 citations
Incremental learning (IL) aims to continually acquire new knowledge (plasticity) while retaining previously learned information (stability). However, striking a balance between plasticity and stability remains a significant challenge for intelligent systems. The human brain achieves exceptional balance, owing to variou...
Wenju Sun, Qingyong Li, Boyang Li et al.· IEEE Transactions on Pattern...· 0 citations
This work argues that explicitly modeling at the functional motif level provides both mechanistic insight into sequence-function relationships and interpretable control over protein generation, an important step toward compositional design of novel protein functions.
Boon How Low, W. Goh, Boyang Li et al.· Proceedings of the 32nd ACM...· 0 citations
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