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Author

Bo-Yang Yu

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Open access Sep 2026

Ruscogenin attenuates sepsis-induced multiple organ injury by inhibiting NMMHC IIA.

Sepsis-induced endothelial dysfunction contributes to systemic inflammation and multiple organ injury. Non-muscle myosin heavy chain IIA (NMMHC IIA) has emerged as a potential therapeutic target for sepsis. However, effective interventions remain limited. This study investigated whether ruscogenin (RUS) alleviates seps...

Jia-Hui Tang, Hai-Yu Chen, Meng-Chen Xu et al. · 0 citations
Aug 2026

Cardiac ACY1 ameliorates pathological hypertrophy by suppressing β-catenin/TCF4 signaling.

The findings establish the ACY1/β-catenin/TCF4/TCF4/UCHL1 pathway as a fundamental mechanism in disease progression, thereby proposing the enhancement of ACY1 function as a rational and innovative strategy to treat pressure-overload heart failure.

Yangxian Chen, Qiong Lai, Shengai Ye et al. · 0 citations

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