Open access
Sep 2026
PTEN-L inhibits mitophagy and GSDME-dependent pyroptosis via Parkin dephosphorylation.
Mitochondrial dysfunction is a potent trigger of inflammatory cell death; however, the precise signaling pathways linking mitochondrial damage to pyroptosis remain incompletely understood. Here, we identify a previously unrecognized pathway in which mitochondrial depolarization activates the PINK1-Parkin axis to drive...
Cheng-Hao Yan, Cai-Nian Huang, Xu Liu et al.
· EMBO Reports · 0 citations