Author

Bob van Puffelen

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Open access Oct 2026

Uridine Bisphosphonate-Carbagalactose: A Stabilized α‑1,4-Galactosyltransferase Inhibitor

Methylene and difluoromethylene uridine bisphosphonate carbagalactose were designed and synthesized as stable uridine diphosphate-galactose (UDP-Gal) mimics for probing α-1,4-galactosyltransferase (A4GALT). In these analogues, the labile glycosidic and pyrophosphate linkages of UDP-Gal are replaced by chemically and en...

Jian-Yun Guo, Nicky de Koster, Bob van Puffelen et al. · Organic Letters · 0 citations

Open access Jul 2026

Identification of cellular intermediates unveils unique enzymes for flagellar glycan biosynthesis in Clostridioides difficile.

This study chemically synthesized two hitherto undescribed biosynthetic intermediates that were predicted based on bioinformatic analyses, CDP-threonine and CDP-N-methylthreonine, and showed that they are involved in the Type A PGM biosynthesis, as evidenced by mass spectrometric analyses of extracts of a set of C. dif...

P. Hensbergen, Bob van Puffelen, Nina Musch et al. · Proceedings of the National... · 0 citations