This review discusses how XL-MS has advanced from targeted analysis of viral protein complexes to structure-resolved mapping of virion architecture and infected-cell virus-host interactomes, and highlights how XL-MS complements AP-MS, cryo-EM/cryo-ET, quantitative proteomics, genetic perturbation, and structure predict...
Boris Bogdanow, Fan Liu· Current Opinion in Chemical...· 0 citations
A virion-wide spatial and quantitative protein proximity map of herpes simplex virus 1 (HSV-1) is defined by combining cross-linking mass spectrometry with quantitative proteomics, showing how conserved organizational principles shape virus-specific virion interaction networks during herpesvirus maturation.
Lars Mühlberg, Yannick Jensen, Julia Ruta et al.· bioRxiv· 0 citations
In-cell cross-linking mass spectrometry maps protein contacts in influenza-infected human cells, revealing how the virus hijacks host membrane-trafficking factors and dismantles nuclear paraspeckles to enhance replication.
I. Kotova, Lars Mühlberg, Konstantin Gilep et al.· Nature Microbiology· 1 citation
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