Spatial multi omic profiling maps hypoxia-driven pro-fibrotic SPP1+ macrophages underpinning immune escape and TACE resistance in hepatocellular carcinoma
An integrative spatial multi-omics strategy, combining bulk and single-cell RNA sequencing, subcellular-resolution spatial transcriptomics, and spatial proteomics on tissues from TACE-treated and treatment-naïve HCC patients, presents a potential therapeutic strategy to overcome TACE resistance and improve clinical out...