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Few studies have investigated how different Alzheimer's disease biomarker definitions affect predictions of cognitive decline.
A stochastic optimization strategy that processes mini-batches of the data, substantially improving scalability and accelerating computation through random data compression and leverage repulsive point processes to diversify mini-batches, reducing redundancy and the variance of updates is introduced.
Effective CSF motility is identified as an important physiological determinant of soluble Aβ levels in plasma and CSF, linking regional CSF dynamics to in vivo Aβ transport and turnover, with potential relevance to cerebral amyloid angiopathy and Alzheimer’s disease.
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