Open access
Oct 2026
Small-Molecule Modulators of HIPK4 Activity and Proteostasis
The discovery of a cyanoquinoline-based series of HIPK4 inhibitors with nanomolar potency is reported, establishing cyanoquinoline ligands as a new chemotype for probing HIPK4 biology and advancing male contraceptive discovery.
Zai-Le Zhuang, Riley K. Togashi, P. Kearney et al.
· Journal of the American Chem... · 0 citations