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Brandon Klein

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Open access Jul 2026

Validation of an UHPLC–MS/MS Assay for the Quantification of Isoniazid and Four Major Metabolites in Human Plasma

An assay consisting of two UHPLC–MS/MS methods was developed and validated to determine concentrations of INH and four of its metabolites in human plasma to help facilitate a better understanding of INH metabolite disposition and relationships with toxicity.

David Nerguizian, Brandon Klein, Farah Abdelmawla et al. · 0 citations