Structural optimization of novel 1,3,4-oxadiazole-based antibacterial compounds for improved stability.
A 1,3,4-oxadiazole-based compound named 1771 and its derivatives have been reported to exhibit antibacterial activity against Gram-positive bacteria, with activity extending to Gram-negative pathogens upon disruption of the outer membrane permeability barrier and/or efflux pump systems. However, the precise mode of act...