Author

Brendan D. Manning

2 papers indexed here

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Open access Aug 2026

Dietary protein governs the role of insulin signaling in the postprandial regulation of hepatic mTORC1

The nutrient-sensing mechanistic target of rapamycin complex 1 (mTORC1) signaling pathway controls cellular and organismal growth and metabolism, and aberrant activation is linked to human disease, including metabolic disease. Cellular studies have established regulatory mechanisms influencing mTORC1 activation, but th...

Krystle C. Kalafut, Y. Cormerais, Madi Y. Cissé et al. · Nature Communications · 1 citation

Open access Sep 2026

Feeding-induced muscle mTORC1 signaling regulates postprandial protein synthesis and endurance but not muscle size.

Activation of the mechanistic target of rapamycin (mTOR) complex1 (mTORC1) promotes muscle protein synthesis, mass, and function. Muscle mTORC1 can be activated by feeding and contraction. Here, muscle mTORC1 signaling, protein synthesis, mass, and function are characterized in a genetic mouse model that separates thes...

Samuel C. Lapp, Krystle C. Kalafut, Madi Y. Cissé et al. · JCI Insight · 0 citations