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Brennan Abanades

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Open access Sep 2026

MIMOSA: Guiding De Novo Antibody Design with Natural Interaction Fingerprints

De novo antibody design promises to transform therapeutic antibody and nanobody discovery. Yet, success remains inconsistent across targets, with generative models often yielding no experimentally validated binders. Here we introduce MIMOSA (MIMic-Oriented Structural Antibody generation), a model-agnostic, inference-ti...

Brennan Abanades, Andrea Roncoli, Maniraj Bhagawati et al. · 0 citations
Open access Aug 2026

Mimic antibodies: leveraging ligand mimicry for epitope-targeted antibody discovery

The concept of mimic antibodies–antibodies that recapitulate the binding mode of a target’s cognate ligand is investigated and established as a promising strategy for rational antibody selection, engineering, and design, with broad implications for therapeutic antibody development and drug discovery.

Brennan Abanades, Joanan López-Morales, Ivana Tanasijević et al. · 2 citations

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