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Brennan Garland

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Open access Aug 2026

Loss of Sox10 prevents tumor initiation in vivo and induces luminal-to-basal reprogramming in Neu+ tumor cells.

It is demonstrated that Sox10 is required for a permissive luminal cell state for Neu-driven tumor initiation and that it is critical for cancer stem cell activity and the establishment of metastases.

Brennan Garland, Samuel Delisle, John Abou-Hamad et al. · 0 citations