Author

Brent Van Bosstraeten

2 papers indexed here

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Open access Sep 2026

High-affinity ELR+ CXC chemokines display balanced G protein-, GRK- and β-arrestin-associated transducer engagement at the viral G protein-coupled receptor ORF74

Open reading frame 74 (ORF74) is the single G protein-coupled receptor (GPCR) encoded in the genome of Kaposi’s sarcoma-associated herpesvirus (KSHV). Due to its high constitutive activity and broad chemokine binding profile, ORF74 contributes to KSHV-associated diseases through autocrine and paracrine mechanisms tha...

Qian-Qian Kong, Brent Van Bosstraeten, S. de Jonghe et al. · Frontiers in Pharmacology · 0 citations

Open access Aug 2026

Identification of CXCL13 as an agonist and CXCL11 as an inverse agonist for the viral G protein-coupled receptor ORF74.

CXCL13 and CXCL11 are revealed as two additional chemokine ligands for ORF74, further expanding the pharmacological profile of this viral GPCR.

Qian-Qian Kong, Brent Van Bosstraeten, S. de Jonghe et al. · Biochemical Pharmacology · 1 citation