Author

Brett A. McGregor

2 papers indexed here

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Open access Oct 2026

scGEN: Leveraging an Adaptive Weighting Strategy for Challenging Cell Clustering in Single‐Cell RNA‐seq

ABSTRACT Recent advancements in single‐cell RNA sequencing (scRNA‐seq) have greatly enhanced our ability to dissect cellular heterogeneity. However, unsupervised clustering often struggles to identify transitional or developmental boundary cells, as existing methods rely on highly variable genes without considering exp...

Fang Huang, Da-Yu Hu, Ya-Qi Dai et al. · Advancement of science · 0 citations

Open access Aug 2026

Bidirectional phenotypic transition in macrophages influences triple-negative breast cancer cell immune evasive patterns and response to chemotherapies in a co-culture spheroid model

An effective 3D co-culture system of breast cancer cells and integrated macrophages for studying dynamic cellular phenotype changes and reciprocal interactions in a heterogeneous environment to mimic aspects of the TME and enhance the accuracy of preclinical in vitro treatment response studies is presented.

Chen Cheng, Brett A. McGregor, J. Hur et al. · PLoS ONE · 0 citations