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Author

Brian A. Boone

2 papers indexed here

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Open access Sep 2026

Exploratory single‐nucleus multiomics analysis of myeloid cell states associated with neoadjuvant chemotherapy response in pancreatic ductal adenocarcinoma

Abstract Background Pancreatic ductal adenocarcinoma (PDAC) continues to be one of the most lethal human malignancies, with the vast majority of patients ineligible for immunotherapy. Tumour‐associated macrophages (TAMs) are key regulators of the PDAC tumour microenvironment (TME), yet their transcriptional and epigeno...

M. Ojetunde, Li Ma, Hillary G. Goodney et al. · 0 citations
Sep 2026

Abstract B015: Targeting myeloperoxidase delays pancreatic cancer growth and enhances chemotherapy response

Pancreatic cancer remains one of the deadliest diseases, with fewer than 13% of patients surviving beyond 5 years after diagnosis. Its resistance to current therapies is driven in part by a uniquely immunosuppressive tumor microenvironment, primarily characterized by an extensive infiltration of tumor-associated myel...

Angisha Basnet, Kaitlyn M. Landreth, Benjamin C. Duncan et al. · 0 citations

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