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Author

Brian Glennon

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Open access Sep 2026

Next-gen glycoengineering: combining cellular and metabolic engineering to fine-tune mAb β1,4-galactosylation

N-linked Fc galactosylation drives variability in therapeutic mAb quality, affecting complement-dependent cytotoxicity and ADCC. Current control strategies suffer from narrow ranges, productivity loss, or unwanted glycoforms. Here, we combine metabolic and cellular glycoengineering by feeding 2-deoxy-2-fluorogalactose...

Apostolos Tsopanoglou, Mina Ghahremanzamaneh, Itzcóatl Gómez Aquino et al. · 0 citations
Open access Aug 2026

Modified Plasmids and Inverted Terminal Repeats Enhance Adeno-Associated Virus Production and Performance

A 140% increase in pHelper plasmid production is reported, while the most successful ITR variant increased pTransgene plasmid yields by 57% and transgene expression by 28%, without reducing rAAV yields or transduction efficiency.

Nicholas Donohue, Alexandra Bogdanovic, James Conheady et al. · 0 citations

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