Author

Brian H. Kim

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Open access Aug 2026

Cholesterol differentially regulates α-synuclein binding across membrane packing regimes

α-Synuclein (αSyn) is an intrinsically disordered protein that preferentially binds anionic membranes with lipid packing defects. Cholesterol is an abundant membrane component that regulates packing and organization within membranes, yet its effect on αSyn binding remains unclear, as prior studies report both cholester...

O. Kou, Brian H. Kim, David H. Johnson et al. · Biophysics Reports · 0 citations

Open access Aug 2026

Membrane Phase, Charge, and Curvature Regulate α-Synuclein Binding Dynamics.

It is established that αSyn-membrane interactions are governed by a cooperative interplay between membrane phase, curvature, and charge and highlight the importance of resolving both thermodynamic and kinetic contributions to protein-membrane binding.

O. Kou, Cailyn M. Sakurai, Stephanie Y. Ramirez et al. · Langmuir · 0 citations