Author

Brian L. Hie

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Open access Aug 2026

Aligning protein-generative models to experimental fitness with ProteinDPO.

This work demonstrates how to provide task-specific information without losing the general knowledge learned during pretraining by using direct preference optimization to align a structure-conditioned protein language model to preferentially generate stable protein sequences.

Talal Widatalla, Ashir Borah, Samuel H. King et al. · Nature Methods · 0 citations

Open access Jul 2026

Machine learning-assisted directed evolution of plant Rubisco

The utility of ML-assisted evolution for engineering Rubisco with improved carboxylation efficiency and potential for enhancing crop productivity is demonstrated.

Julie L. McDonald, Jiachen Lin, Yunlong Zhao et al. · bioRxiv · 0 citations