Author

Brian Melo

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Oct 2026

Site-Specific N-Glycan-Resolved PK Assessment of Therapeutic Proteins Using Hybrid LBA-HRMS and LC-MS/MS

Understanding how glycosylation and its metabolic conversion shape the pharmacokinetics (PK) and pharmacodynamics (PD) of therapeutic proteins is essential for predicting exposure and efficacy. Lot-to-lot comparisons typically rely on aggregate PK metrics that obscure contributions from individual glycoforms, despite...

Inês C. Santos, Bonnie Wang, Jarred Burke et al. · Analytical Chemistry · 0 citations

Aug 2026

A DAR sensitive hybrid LBA-LC-MS/MS assay for quantitation of conjugated payload from a non-cleavable ADC in human serum.

BACKGROUND Quantitating antibody drug conjugates (ADCs) with traditional ligand binding assays (LBAs) requires cytotoxic payload targeting reagents, which may be needed for ADC capture/detection. LBAs are drug antibody ratio insensitive (DAR insensitive) and prone to under- or over-estimating DAR species. METHODS Thi...

Yong-Jun Xue, Eric Ma, Brian Melo et al. · Bioanalysis · 0 citations