Author

Briana L. Sobecks-Doherty

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Open access Aug 2026

Structural basis for nutrient-activated channel opening in bacterial spore germination receptors

GerA-family germinant receptors were recently identified as ion channels that initiate germination of dormant bacterial spores in response to nutrients. Here we report 2.0-Å cryo-electron microscopy structures of apo, agonist-bound, and antagonist-bound GerA, revealing a symmetric pentamer of heterotrimers. Signaling r...

Joshua C. Cofsky, Fernando H. Ramírez-Guadiana, Briana L. Sobecks-Doherty et al. · bioRxiv · 0 citations

Open access Sep 2026

Mechanism of gating and isoform-specific inhibition in renal CLC chloride channels.

Hyponatremia is a prevalent disorder marked by excess water retention and substantial morbidity, motivating interest in the chloride channel CLC-Ka as a therapeutic target. Selectively inhibiting CLC-Ka without affecting the closely related CLC-Kb is essential for preventing serious side effects. However, developing is...

Chih-Ta Chien, Briana L. Sobecks-Doherty, A. Powers et al. · Proceedings of the National... · 0 citations